Hydroxychloroquine vs plaquenil drogas


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Quiénes están acopiando cloroquina, una de las drogas a las que apuesta EEUU contra el coronavirus

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Nuestra Garantía es su Seguridad. Existe evidencia creciente del uso de HCQ en pacientes con SAF refractario a tratamientos convencionales o recurrentes bajo medicación antitrombótica. Un estudio clínico prospectivo no aleatorizado, desarrollado por un grupo francés, incluyó 40 pacientes con SAF con eventos tromboembólicos venosos, no arteriales ni obstétricos.

Por lo tanto, el tratamiento con HCQ podría llegar a constituir una herramienta valiosa en la prevención secundaria del SAF primario Hidroxicloroquina en otras enfermedades autoinmunes sistémicas. Al igual que ocurre con otras EAS, la base del tratamiento lo constituye el uso de glucocorticoides en conjunto con inmunosupresores. Los ensayos clínicos son escasos en estas enfermedades, por lo que la información procede de series de casos, estudios retrospectivos u opinión de expertos. En sarcoidosis también existen reportes que sugieren beneficios del tratamiento con HCQ, particularmente en lesiones musculoesqueléticas, ganglionares y pulmonares Algo similar ocurre en la enfermedad de Still, en que se han sugerido beneficios del tratamiento con HCQ en combinación con metotrexate y sulfasalazina Se destaca su impacto favorable en diversas variables clínicas y particularmente en el aumento de la sobrevida en el LES.

En el síndrome de Sjögren su eficacia es de menor impacto, pero igualmente importante en una enfermedad con opciones terapéuticas limitadas. En el síndrome antifosfolipídico se destaca que su efecto antitrombótico es especialmente atractivo como terapia adyuvante en pacientes con eventos trombóticos recurrentes. Algo similar ocurre en el tratamiento de la sarcoidosis. Su perfil de seguridad es muy favorable.

Sus efectos adversos son escasos. La toxicidad retiniana es motivo de preocupación aunque su frecuencia no es elevada. Se requieren controles periódicos para pesquisar precozmente lesiones predisponentes y potencialmente reversibles. Otros efectos adversos deben ser tenidos en cuenta y monitorizados.


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Puede ser usada con razonable seguridad en el embarazo y la lactancia. Orientación diagnóstica basada en la clínica y el laboratorio. Barcelona, España: Editorial Masson S. Systemic lupus erythematosus. Lancet ; : Smolen JS, Aletaha D. Rheumatoid arthritis therapy reappraisal: strategies, opportunities and challenges. Nat Rev Rheumatol Wallace DJ. The use of quinacrine Atabrine in rheumatic diseases: a reexamination. Semin Arthritis Rheum ; 18 4 : Furst DE. Pharmacokinetics of hydroxychloroquine and chloroquine during treatment of rheumatic diseases. Lupus ; 5 Suppl 1: S Therapy and pharmacological properties of hydroxychloroquine and chloroquine in treatment of systemic lupus erythematosus, rheumatoid arthritis and related diseases.

Relationship between blood hydroxychloroquine concentrations and cigarette smoking in trated patients with connective tissue diseases. Ann Rheum Dis ; 66 11 : Influence of smoking on the efficacy of antimalarials in cutaneous lupus: a meta-analysis of the literatura. J Am Acad Dermatol ; 72 4 : Hydroxychloroquine: a multifaceted treatment in lupus. Presse Med ; New insights into mechanisms of therapeutic effects of antimalarial agents in SLE.

Nat Rev Rheumatol ; 8 9 : Multifaceted effects of hydroxychloroquine in human disease. Semin Arthritis Rheum ; Kalia S, Dutz JP. New concepts in antimalarial use and mode of action in dermatology. Dermatol Ther ; The role of antimalarials in the exacerbation of psoriasis: a systematic review. Am J Clin Dermatol ; 7: Hydrochloroquine retinopathy: characteristic presentation with review of screening. Clin Rheumatol ; Clinical efficacy and side effects of antimalarials in systemic lupus erythematosus: a systematic review.

Ann Rheum Dis ; Revised recommendations on screening for chloroquine and hydroxychloroquine retinopathy. Ophthalmology ; Cardiomyopathy related to antimalarial the-rapy with Iillustrative case report. Cardiology ; State of the art: Reproduction and pregnancy in rheumatic diseases.

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Autoimmun Rev ; 14 5 : Hidroxicloroquina en el embarazo y la lactancia. Rev Med Urug ; 31 2 : Hydroxychloroquine: the cornerstone of lupus therapy. Lupus ; Systemic lupus erythematosus in three ethnic groups: XVI. Association of hydroxychloroquine use with reduced risk of damage accrual. Arthritis Rheum ; 52 5 : Petri M. Hydroxychloroquine use in the Baltimore Lupus Cohort: effects on lipids, glucose and thrombosis.

Hydroxychloroquine use predicts complete renal remission within 12 months among patients treated with mycophenolate mofetil therapy for membranous lupus nephritis. Lupus ; 15 6 : Glucocorticoid use and abuse in SLE. Rheumatology Oxford ; 51 7 : A randomized study of the effect of withdrawing hydroxychloroquine sulfate in systemic lupus erythematosus.

La hidroxicloroquina, un fármaco potencialmente letal | Medicina Intensiva

The Canadian Hydroxychloroquine Study Group. N Engl J Med ; 3 : A long-term study of hydroxychloroquine withdrawal on exacerbations in systemic lupus erythematosus. Lupus ; 7 2 : The early protective effect of hydroxychloroquine on the risk of cumulative damage in patients with systemic lupus erythematosus. J Rheumatol ; 40 6 : Risk factors associated with mortality in systemic lupus erythematosus.

Plaquenil y sus ojos

A case-control study in a tertiary care center in Mexico City. Clin Exp Rheumatol ; 19 4 : Effect of antimalarials on thrombosis and survival in patients with systemic lupus erythematosus. Lupus ; 15 9 : Ann Rheum Dis ; 66 9 : Tratamiento del lupus eritematoso sistémico: mitos, certezas y dudas. Med Clin Barc ; 12 : Current evidence for the management of rheumatoid arthritis with synthetic disease-modifying antirheumatic drugs: a systematic literature review informing the EULAR recommendations for the management of rheumatoid arthritis. Ann Rheum Dis ; 69 6 : Hydroxychloroquine use and decreased risk of diabetes in rheumatoid arthritis patients.

J Clin Rheumatol ; 17 3 : Triple therapy in early active rheumatoid arthritis: a randomized, single-blind, controlled trial comparing step-up and parallel treatment strategies. Arthritis Rheum ; 58 5 : EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs: update. Ann Rheum Dis ; 73 3 : Primary Sjögren syndrome: an update on current pharmacotherapy options and future directions. Expert Opin Pharmacother ; 14 3 : Rheumatol Int ; 31 8 : Rheumatology Oxford ; 48 7 : Treatment of primary Sjögren syndrome: a systematic review.

JAMA ; 4 : Loudon JR. Hydroxychloroquine and postoperative thromboembolism after total hip replacement. Am J Med ; Hydroxychloroquine reverses thrombogenic properties of antiphospholipid antibodies in mice.

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